Stereochemical Aspects of Nucleophilic Substitution Reactions of Haloalkanes and Haloarenes

Which of the following structures represents a chiral compound?

What kind of reagent would be needed to resolve a racemic amine, such as 2-aminobutane?

Number of chiral centers in the above molecule are:

A pure simple of $2$-chlorobutane shows rotation of PPL by ${30}^{\mathrm{o}}$ in standard conditions. When above samples is made impure by mixing its opposite form, so that the composition of the mixture become $87.5 \%$ $\mathrm{d}$-form and $12.5 \%$ $\mathrm{l}$-form, then what will be the observed rotation for the mixture.

Explain relative configuration with the help of an example.

Define the term relative configuration.

Write difference between absolute and relatvie configuration.

What is relative configuration.

If during a reaction, no bond to the stereocentre is broken, than the reaction will proceed with retention of the configuration.

The preservation of integrity of the spatial arrangement of bonds to an asymmetric centre during a chemical reaction is called inversion of configuration.

If during a reaction, the product has the same general configuration of groups around the stereocentre as that of reactant. Such a reaction is said to proceed with:

For a laevorotatory compound a negative ($-$) sign is placed before the degree of rotation.

A compound that rotates the plane polarised light in the anticlockwise direction, is said to be laevorotatory.

Explain the retention of configuration with an example.

Differentiate between dextrorotatory and laevorotatory compounds.

If the configuration of optically active remains unchanged during the reaction, it is called _____.

Define a laevorotatory compound.

Which of the following method is not used in the resolution of a racemic mixture?

Which of the following is taken as a reference to represent the relative configuration?

Which of the following compounds will give racemic mixture on nucleophilic substitution by ${\mathrm{OH}}^{-}$ ion?